Fabrication and Evaluation of Carboxy Methyl Cellulose Anchored Dextran Bioinspired Hydrogel for Effective Delivery of Piroxicam

The main focus of the work was to develop a hydrogel carboxy methyl cellulose tailored dextran containing piroxicam intended for transdermal delivery. Firstly, formulated by conjugation with amino and then mixed encapsulation in matrix. characterization performed terms zeta potential, entrapment efficiency, morphology vitro drug release. size particles found 134 nm cellulose-dextran hydrogels efficiency observed as 87.36 %±1.23 % 72.35 %±2.35 case hydrogels, respectively. An vivo study loaded formulation according more (6.22 mg/ml) than (plain) concentration plasma (3.21 mg/ml). Carboxy epidermis, retained 15.61±1.5 mg/ml dermis it 6.24 %±1.2 well epidermis retention 5.21±1.19 26.34±0.5 12 h. Piroxicam were effective wound healing through improved collagen protein content, restoration antioxidants granuloma tissues.